Atinvicitinib

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Chemical Structure : Atinvicitinib

CAS No.: 2169273-59-8

Catalog No.: PC-73400Not For Human Use, Lab Use Only.

Atinvicitinib is a pyrazole compound and JAK inhibitor with IC50 of 0.4, 6 and 13 nM against JAK1, JAK2, and TYK2, less potent for JAK3 (IC50=1130 nM), has the potential for the research of atopic dermatitis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Atinvicitinib is a pyrazole compound and JAK inhibitor with IC50 of 0.4, 6 and 13 nM against JAK1, JAK2, and TYK2, less potent for JAK3 (IC50=1130 nM), has the potential for the research of atopic dermatitis.

Physicochemical Properties

M.Wt	360.34
Formula	C16H17FN6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-4-carboxamide, 1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridinyl)amino]-

References

1. Tony Siu, et al. J Med Chem. 2017 Dec 14;60(23):9676-9690.

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Atinvicitinib

Biological Activity

Physicochemical Properties

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