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Chemical Structure : Atiprimod dihydrochloride
Catalog No.: PC-63194Not For Human Use, Lab Use Only.
Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.
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Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.
Atiprimod efficaciously inhibits the proliferation of FDCP-EpoR JAK2 (V617F) (IC50=0.42 uM) and SET-2 cells (IC50= 0.53 uM).
Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells (MM.1S, U266, and RPMI8226 MM cell lines IC50=0.5-1.25 uM), significantly inhibits production of IL-6 and inflammation in rat arthritis and autoimmune animal models.
| M.Wt | 409.524 | |
| Formula | C22H46Cl2N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Quintás-Cardama A, et al. Invest New Drugs. 2011 Oct;29(5):818-26.
2. Neri P, et al. Leukemia. 2007 Dec;21(12):2519-26.
3. Hamasaki M, et al. Blood. 2005 Jun 1;105(11):4470-6.
4. Choudhari SR, et al. Mol Cancer Ther. 2007 Jan;6(1):112-21.
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