Catalog No.: PC-24417Not For Human Use, Lab Use Only.
Aurantiamide is a potent, non-covalent, orally active, BBB-permeable antagonist of gastrin-releasing peptide receptor (GRPR), shows anti-inflammatory and neuroprotective effects.
Aurantiamide is a potent, non-covalent, orally active, BBB-permeable antagonist of gastrin-releasing peptide receptor (GRPR), shows anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models.
