Chemical Structure : AurkinA
CAS No.:
1534060-58-6
AurkinA
(Aurkin A, Aurkin-A)
Catalog No.: PC-22459Not For Human Use, Lab Use Only.
AurkinA (Aurkin A) is a chemical inhibitor of the AURKA-TPX2 interaction and potent allosteric inhibitor of Aurora A (AURKA), shows binding affinity to AURKA with ITC Kd of 3.77 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AurkinA (Aurkin A) is a chemical inhibitor of the AURKA-TPX2 interaction and potent allosteric inhibitor of Aurora A (AURKA), shows binding affinity to AURKA with ITC Kd of 3.77 uM.
AurkinA binds to a pocket occupied by Y8 and Y10 of TPX2 in the AURKA-TPX2 complex (the Y-pocket), triggers conformational changes in AURKA protein.
AurkinA inhibits the kinase activity of AURKA in an ATP-independent manner.
AurkinA mislocalises AURKA from the bipolar spindle in mitotic cells.
AurkinA disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma.
Physicochemical Properties
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M.Wt
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346.16
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Formula
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C16H9BrFNO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(3-bromophenyl)-8-fluoroquinoline-4-carboxylic acid
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References
1. Janeček M, et al. Sci Rep. 2016 Jun 24;6:28528.
2. Lee H, et al. Bioorg Med Chem. 2024 Mar 15;102:117658.
3. Conway PJ, et al. Neoplasia. 2024 Jun 13;55:101014.
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