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Chemical Structure : AurkinA
Catalog No.: PC-22459Not For Human Use, Lab Use Only.
AurkinA (Aurkin A) is a chemical inhibitor of the AURKA-TPX2 interaction and potent allosteric inhibitor of Aurora A (AURKA), shows binding affinity to AURKA with ITC Kd of 3.77 uM.
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AurkinA (Aurkin A) is a chemical inhibitor of the AURKA-TPX2 interaction and potent allosteric inhibitor of Aurora A (AURKA), shows binding affinity to AURKA with ITC Kd of 3.77 uM.
AurkinA binds to a pocket occupied by Y8 and Y10 of TPX2 in the AURKA-TPX2 complex (the Y-pocket), triggers conformational changes in AURKA protein.
AurkinA inhibits the kinase activity of AURKA in an ATP-independent manner.
AurkinA mislocalises AURKA from the bipolar spindle in mitotic cells.
AurkinA disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma.
| M.Wt | 346.16 | |
| Formula | C16H9BrFNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Janeček M, et al. Sci Rep. 2016 Jun 24;6:28528.
2. Lee H, et al. Bioorg Med Chem. 2024 Mar 15;102:117658.
3. Conway PJ, et al. Neoplasia. 2024 Jun 13;55:101014.
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