Avacopan | C5aR inhibitor | Probechem Biochemicals

Chemical Structure : Avacopan

CAS No.: 1346623-17-3

Avacopan (CCX-168, CCX168)

Catalog No.: PC-60245Not For Human Use, Lab Use Only.

Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
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Biological Activity

Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.
Avacopan (CCX-168, CCX168) shows no activity (IC50 >5,000 nM) for C5aR-related receptors C5L2, C3aR, ChemR23, GPR1 and FPR.
Avacopan (CCX-168, CCX168) inhibits C5a-mediated chemotaxis of U937 cells with pA2 of 0.2 nM.
Avacopan (CCX-168, CCX168) shows activity in mouse model of ANCA-induced glomerulonephritis.

Physicochemical Properties

M.Wt	581.656
Formula	C33H35F4N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide

References

1. Xiao H, et al. J Am Soc Nephrol. 2014 Feb;25(2):225-31.

2. Bekker P, et al. PLoS One. 2016 Oct 21;11(10):e0164646.

3. Jayne DRW, et al. J Am Soc Nephrol. 2017 Sep;28(9):2756-2767.

Avacopan (CCX-168, CCX168)

Biological Activity

Physicochemical Properties

References

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