| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-35445 |
Danicopan
|
1903768-17-1 |
Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM. |
| PC-61821 |
NDT 9513727
|
439571-48-9 |
NDT 9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay. |
| PC-60253 |
Leukadherin 1
|
344897-95-6 |
Leukadherin 1 (LA1) is a small molecule allosteric agonist of integrin CD11b/CD18 (CR3), increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50=4 uM). |
| PC-60245 |
Avacopan
|
1346623-17-3 |
Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM. |
| PC-45881 |
BCX-1470
|
217099-43-9 |
BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM). |
| PC-38358 |
Vemircopan
|
2086178-00-7 |
Vemircopan (ALXN2050, ACH 5228) is a second generation, orally active complement factor D inhibitor, has the potential to decrease disease symptoms and increase strength in generalized myasthenia gravis (gMG). |
| PC-38352 |
JYN42346
|
1903742-34-6 |
JYN42346 (Complement factor D-IN-2) is an inhibitor of complement factor D. |
