| Cat. No. |
Product Name |
Information |
| PC-21586 |
C1s inhibitor A1
C1s inhibitor
|
C1s inhibitor A1 is a selective, competitive inhibitor of complement component C1s with binding Kd of 9.8 uM, competitively inhibits its activity with Ki of 5.8 uM. |
| PC-38846 |
W54011
C5a antagonist
|
W-54011 (W54011) is a potent, selective, orally active and non-peptide C5a receptor antagonist, inhibits the binding of 125I-labeled C5a to human neutrophils with Ki of 2.2 nM. |
| PC-38845 |
PMX205
C5aR inhibitor
|
PMX205 is a potent, selective C5a receptor peptide antagonist with IC50 of 30 nM. |
| PC-38358 |
Vemircopan
Factor D inhibitor
|
Vemircopan (ALXN2050, ACH 5228) is a second generation, orally active complement factor D inhibitor, has the potential to decrease disease symptoms and increase strength in generalized myasthenia gravis (gMG). |
| PC-38352 |
JYN42346
Factor D inhibitor
|
JYN42346 (Complement factor D-IN-2) is an inhibitor of complement factor D, inhibits the complement cascade at an early and essential point in the alternative complement pathway. |
| PC-73000 |
C5 complement inhibitor 7
C5 complement inhibitor
|
C5 complement inhibitor 7 (C5-IN-7) is a potent, small-molecule inhibitor of C5 complement protein with serum assay IC50 of <5 nM (2% human serum complement inhibition). |
| PC-72455 |
AMY-101
C3 inhibitor
|
AMY-101 (Cp40) is a peptidic inhibitor of the central complement component C3 for the management of patients with ARDS caused by SARS-CoV-2 infection. |
| PC-72006 |
C3aR antagonist JR14a
C3aR antagonist
|
C3aR antagonist JR14a is a potent and selective antagonist of human Complement C3a receptor (hC3aR) with IC50 of 10 nM (Inhibition of intracellular Ca2+ release induced by 100 nM C3a). |
| PC-72001 |
JPE1375
C5aR inhibitor
|
JPE1375 is a potent, peptidomimetic C5a receptor antagonist with IC50 of 39 nM, inhibits neutrophil influx in the RPAR in mice. |
| PC-72000 |
BM213
C5aR1 agonist
|
BM213 (BM-213) is a potent, selective and stable peptide C5aR1 agonist with EC50 of 59 nM. |
| PC-38339 |
DF2593A
C5aR inhibitor
|
DF2593A (DF 2593A) is a potent, selective, noncompetitive allosteric inhibitor of C5aR with IC50 of 5 nM (C5a-induced human PMN migration inhibition), and rat and mouse orthologs (IC50=6.0 nM and IC50=1.0 nM, respectively). |
| PC-38338 |
DF3016A
C5aR inhibitor
|
DF3016A (DF 3016A) is a potent and selective C5aR inhibitor with IC50 of 50 nM (C5a-induced human PMN migration and IC50 of 45 and 37 nM against rat and mouse C5aR, respectively. |
