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Chemical Structure : C5 complement inhibitor 7
CAS No.: 2365402-67-9
Catalog No.: PC-73000Not For Human Use, Lab Use Only.
C5 complement inhibitor 7 (C5-IN-7) is a potent, small-molecule inhibitor of C5 complement protein with serum assay IC50 of <5 nM (2% human serum complement inhibition).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $458 | In stock | |
| 25 mg | $958 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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C5 complement inhibitor 7 (C5-IN-7) is a potent, small-molecule inhibitor of C5 complement protein with serum assay IC50 of <5 nM (2% human serum complement inhibition).
C5-IN-7 demonstrated excellent potency and good aqueous solubility, inhibited MAC deposition with IC50 of 1 uM in a complement inhibition assay using 50% human whole blood.
The C5 triple mutants (C704R, V705I and N707H) were not inhibited by C5 complement protein inhibitor 7 up to 100 uM.
C5 complement protein inhibitor 7 binds within the predicted pocket between the C5a and MG8 domains in close proximity to the C5 convertase cleavage site (R751-L752).
| M.Wt | 444.528 | |
| Formula | C24H32N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-5-methoxy-2-(3-(1-(2-methoxyphenyl)ethyl)ureido)-4-((4-methylpentyl)oxy)benzoic acid |
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1. Jendza K, et al. Nat Chem Biol. 2019 Jul;15(7):666-668.
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