Catalog No.: PC-24548Not For Human Use, Lab Use Only.
BCX9930 (Pelecopan) is a potent, selective oral inhibitor of complement Factor D with IC50 of 14.3 nM (purified human factor D), inhibits the activation of the complement alternative pathway (AP).
BCX9930 (Pelecopan) is a potent, selective oral inhibitor of complement Factor D with IC50 of 14.3 nM (purified human factor D), inhibits the activation of the complement alternative pathway (AP). BCX9930 does not inhibit enzyme activity of the human serine proteases thrombin, activated protein C, tissue plasminogen activator and trypsin up to 28 μM, and activated factor X and activated factor XII up to 50 μM. BCX9930 also inhibits its proteolytic activity against factor B bound to C3b with a mean IC50 of 28.1 nM. BCX9930 inhibits AP-mediated hemolysis of rabbit erythrocytes with a mean IC50 of 29.5 nM. BCX9930 completely suppresses AP-mediated hemolysis with a mean IC50 of 35.4 nM in erythrocytes from paroxysmal nocturnal hemoglobinuria (PNH) patients. BCX9930 suppresses AP activity of serum measured by AP-dependent generation of C5b-9 in monkeys.
