| Cat. No. |
Product Name |
Information |
| PC-62225 |
Factor D inhibitor 7
Factor D inhibitor
|
Factor D inhibitor 7 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 50 nM. |
| PC-61821 |
NDT9513727
C5aR inhibitor
|
NDT 9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay. |
| PC-61772 |
BR111
C3aR inhibitor
|
BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85 nM (inhibition of hC3a induced Ca2+ release on human macrophages). |
| PC-61771 |
BR103
C3aR inhibitor
|
BR103 is a potent, metabolically stable and highly selective small molecule agonist of complement C3a receptor (C3aR) with EC50 of 22 nM. |
| PC-60789 |
SB290157
C3aR inhibitor
|
SB290157 (SB 290157) is a potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM. |
| PC-60245 |
Avacopan
C5aR inhibitor
|
Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM. |
| PC-45882 |
BCX1470 methanesulfonate
Factor D/C1s inhibitor
|
BCX1470 methanesulfonate is a potent serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM). |
| PC-45881 |
BCX1470
Factor D/C1s inhibitor
|
BCX1470 (BCX 1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM). |
| PC-28511 |
Licancopan fumarate
Factor B inhibitor
|
Licancopan fumarate (HRS-5965) is a potent, selective and orally active complement factor (Factor B) inhibitor, disrupts the formation of C3 convertases within the alternative pathway, thereby halting C3 cleavage and downstream complement activation. |
| PC-27245 |
ZQ105
C5aR2 agonist
|
ZQ105 is a potent, highly selective complement receptor C5aR2 agonist with KD of 1.25 uM, does not activate C5aR1, induces β-arrestin1 recruitment to C5aR2 with pEC50 of 6.02. |
| PC-25604 |
Pegcetacoplan acetate
Complement C3 inhibitor
|
Pegcetacoplan acetate (APL-2) is a pegylated complement C3 inhibitor peptide, acts by binding with complement component 3 (C3) and its activation fragment C3b, inhibits classical and alternative pathways. |
| PC-25087 |
Refinicopan
Factor D inhibitor
|
Refinicopan is a potent, selective complement factor D inhibitor. |
