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Chemical Structure : W54011
CAS No.: 405098-33-1
Catalog No.: PC-38846Not For Human Use, Lab Use Only.
W-54011 (W54011) is a potent, selective, orally active and non-peptide C5a receptor antagonist, inhibits the binding of 125I-labeled C5a to human neutrophils with Ki of 2.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $388 | In stock | |
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| 1 g | Get quote |
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W-54011 (W54011) is a potent, selective, orally active and non-peptide C5a receptor antagonist, inhibits the binding of 125I-labeled C5a to human neutrophils with Ki of 2.2 nM.
W-54011 also inhibited C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of reactive super oxide species in human neutrophils with IC50 values of 3.1, 2.7, and 1.6 nM, respectively.
W-54011 did not show agonistic activity at up to 10 uM in C5a-induced intracellular Ca2+ mobilization assay with human neutrophils.
W-54011 effectively inhibited C5a-induced intracellular Ca2+ mobilization in neutrophils of cynomolgus monkeys and gerbils but not mice, rats, guinea pigs, rabbits, and dogs.
W-54011 (3-30 mg/kg, oral) inhibited C5a-induced neutropenia in a dose-dependent manner in gerbils.
| M.Wt | 493.088 | |
| Formula | C30H37ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1- carboxamide hydrochloride |
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1. Xaria X Li, et al. Biochem Pharmacol. 2020 Oct;180:114156.
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