Catalog No.: PC-38846Not For Human Use, Lab Use Only.
W-54011 (W54011) is a potent, selective, orally active and non-peptide C5a receptor antagonist, inhibits the binding of 125I-labeled C5a to human neutrophils with Ki of 2.2 nM.
W-54011 (W54011) is a potent, selective, orally active and non-peptide C5a receptor antagonist, inhibits the binding of 125I-labeled C5a to human neutrophils with Ki of 2.2 nM.
W-54011 also inhibited C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of reactive super oxide species in human neutrophils with IC50 values of 3.1, 2.7, and 1.6 nM, respectively.
W-54011 did not show agonistic activity at up to 10 uM in C5a-induced intracellular Ca2+ mobilization assay with human neutrophils.
W-54011 effectively inhibited C5a-induced intracellular Ca2+ mobilization in neutrophils of cynomolgus monkeys and gerbils but not mice, rats, guinea pigs, rabbits, and dogs.
W-54011 (3-30 mg/kg, oral) inhibited C5a-induced neutropenia in a dose-dependent manner in gerbils.
