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Chemical Structure : Avasimibe
CAS No.: 166518-60-1
Catalog No.: PC-43398Not For Human Use, Lab Use Only.
Avasimibe (CI-1011, PD-148515) is a potent, selective inhibitor of acyl-CoA: cholesterol O-acyl transferase (ACAT) with IC50 of 60 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $158 | In stock | |
| 100 mg | $258 | In stock | |
| 250 mg | Get quote |
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Avasimibe (CI-1011, PD-148515) is a potent, selective inhibitor of acyl-CoA: cholesterol O-acyl transferase (ACAT) with IC50 of 60 nM.
Avasimibe potently reduces plasma cholesterol in chow-fed rats and in rabbits fed a cholesterol-free, casein-containing diet characterized by both hepatic overproduction of apo B-containing lipoproteins and delayed lipoprotein clearance.
Avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs.
Avasimibe synergistically reduces cholesteryl ester content in THP-1 macrophages combined with Atorvastatin,
| M.Wt | 501.72102 | |
| Formula | C29H43NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester |
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1. Lee HT, et al. J Med Chem. 1996 Dec 20;39(26):5031-4.
2. Ramharack R, et al. Atherosclerosis. 1998 Jan;136(1):79-87.
3. Burnett JR, et al. J Lipid Res. 1999 Jul;40(7):1317-27.
4. Llaverías G, et al. Eur J Pharmacol. 2002 Sep 6;451(1):11-7.
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