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Azosemide

Chemical Structure : Azosemide

CAS No.: 27589-33-9

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Azosemide (Azosemidum)

Catalog No.: PC-35345Not For Human Use, Lab Use Only.

Azosemide (Azosemidum) is a potent Na-K-Cl Cotransporter NKCC1 with IC50 of 0.246 and 0.197 uM for hNKCC1A and NKCC1B, being about 4-times more potent than bumetanide.

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100 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Azosemide (Azosemidum) is a potent Na-K-Cl Cotransporter NKCC1 with IC50 of 0.246 and 0.197 uM for hNKCC1A and NKCC1B, being about 4-times more potent than bumetanide.
Azosemide is a high-ceiling loop diuretic agent used to treat hypertension, edema, and ascites.

Physicochemical Properties

M.Wt 370.83
Formula C12H11ClN6O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide

References

1. Hampel P, et al. Sci Rep. 2018 Jun 29;8(1):9877.

2. Harada K, et al. J Cardiovasc Pharmacol. 2009 Jun;53(6):468-73.

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