B3GNT2 inhibitor 8j

Chemical Structure : B3GNT2 inhibitor 8j

Catalog No.: PC-21378Not For Human Use, Lab Use Only.

B3GNT2 inhibitor 8j is a potent, seletive and orally active inhibitor of β-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) with IC50 of 9 nM, shows no activity against B3GNT2 (IC50>250 uM).

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Biological Activity

B3GNT2 inhibitor 8j is a potent, seletive and orally active inhibitor of β-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) with IC50 of 9 nM, shows no activity against B3GNT2 (IC50>250 uM).

Physicochemical Properties

M.Wt	460.46
Formula	C22H23F3N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((R)-3,3-Dimethylbutan-2-yl)-6-((S)-5-methyl-4-oxo-5-(2-(trifluoromethyl)pyrimidin-5-yl)-4,5-dihydro-1H-imidazol-2-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

References

1. Jackson JJ, et al. J Med Chem. 2023 Nov 21. doi: 10.1021/acs.jmedchem.3c01517.

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