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BAK4-54

Chemical Structure : BAK4-54

CAS No.: 1802038-48-7

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BAK4-54 (BAK 4-54)

Catalog No.: PC-47104Not For Human Use, Lab Use Only.

BAK4-54 is a high affinity dopamine D3 receptor (D3R) antagonist/partial agonist withIC50 of 8.0 nM as full D3R antagonist, EC50 of 140 nM as partial D3R agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BAK4-54 is a high affinity dopamine D3 receptor (D3R) antagonist/partial agonist withIC50 of 8.0 nM as full D3R antagonist, EC50 of 140 nM as partial D3R agonist.
    BAK4-54 (0.4-10 mg/kg, i.p.) dose-dependently decreased oxycodone self-administration, and shifted the oxycodone dose-response curve downward in rats.
    BAK4-54 facilitated extinction and inhibited oxycodone-induced reinstatement of drug-seeking behavior.
    BAK4-54 also dose-dependently decreased oxycodone-enhanced locomotor activity.

    Physicochemical Properties

    M.Wt 426.564
    Formula C27H30N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(4-(Naphthalen-1-yl)piperazin-1-yl)butyl)-1H-indole-2-carboxamide

    References

    1. Zhi-Bing You, et al. Neuropharmacology. 2017 Nov;126:190-199.

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