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Chemical Structure : BAK4-54
Catalog No.: PC-47104Not For Human Use, Lab Use Only.
BAK4-54 is a high affinity dopamine D3 receptor (D3R) antagonist/partial agonist withIC50 of 8.0 nM as full D3R antagonist, EC50 of 140 nM as partial D3R agonist.
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BAK4-54 is a high affinity dopamine D3 receptor (D3R) antagonist/partial agonist withIC50 of 8.0 nM as full D3R antagonist, EC50 of 140 nM as partial D3R agonist.
BAK4-54 (0.4-10 mg/kg, i.p.) dose-dependently decreased oxycodone self-administration, and shifted the oxycodone dose-response curve downward in rats.
BAK4-54 facilitated extinction and inhibited oxycodone-induced reinstatement of drug-seeking behavior.
BAK4-54 also dose-dependently decreased oxycodone-enhanced locomotor activity.
| M.Wt | 426.564 | |
| Formula | C27H30N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhi-Bing You, et al. Neuropharmacology. 2017 Nov;126:190-199.
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