BAL0891

Chemical Structure : BAL0891

Catalog No.: PC-22996Not For Human Use, Lab Use Only.

BAL0891 is a first in class, potent dual TTK/PLK1 inhibitor with IC50 of 0.4/46 nM respectively.

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Biological Activity

BAL0891 is a first in class, potent dual TTK/PLK1 inhibitor with IC50 of 0.4/46 nM respectively.
BAL0891 elicits a prolonged effect on TTK, with a transient activity on PLK1.
BAL0891 induces spindle assembly checkpoint (SAC) disruption and aberrant mitotic exit.
BAL0891 elicits potent, single agent antitumor activity in TNBC mouse xenograft models.
BAL0891 synergizes with paclitaxel and carboplatin in mouse TNBC models.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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BAL0891

Biological Activity

Physicochemical Properties

References

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