Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BAM15
CAS No.: 210302-17-3
Catalog No.: PC-38246Not For Human Use, Lab Use Only.
BAM15 (Mitochondrial uncoupler BAM15) is a potent protonophore that uncouples the mitochondria without depolarizing the plasma membrane, oxidative phosphorylation (OXPHOS) uncoupler.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BAM15 (Mitochondrial uncoupler BAM15) is a potent protonophore that uncouples the mitochondria without depolarizing the plasma membrane, oxidative phosphorylation (OXPHOS) uncoupler.
BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
Compared to FCCP, an uncoupler of equal potency, BAM15 treatment of cultured cells stimulates a higher maximum rate of mitochondrial respiration and is less cytotoxic.
C57BL/6J mice treated with BAM15 were resistant to weight gain.
BAM15-treated mice exhibited improved body composition and glycemic control independent of weight loss, effects attributable to drug targeting of lipid-rich tissues.
| M.Wt | 340.294 | |
| Formula | C16H10F2N6O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
|
1. Zunica ERM, et al. Cancer Metab. 2021 Oct 9;9(1):36.
2. Dang CP, et al. J Innate Immun. 2021;13(6):359-375.
3. Alexopoulos SJ, et al. Nat Commun. 2020 May 14;11(1):2397.
4. Childress ES, et al. J Med Chem. 2020 Mar 12;63(5):2511-2526.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
