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Chemical Structure : BAY-0069
CAS No.: 420826-65-9
Catalog No.: PC-49400Not For Human Use, Lab Use Only.
BAY-0069 (BAY0069) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.22 nM in cellular reporter assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $438 | In stock | |
| 100 mg | Get quote |
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BAY-0069 (BAY0069) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.22 nM in cellular reporter assays.
BAY-0069 displays no signigicant acitivity against PPARA, PPARD and additional high homology PXR (IC50 values >40 uM).
BAY-0069 inhibits proliferation of PPARG-amplified cell line UM-UC-9 with IC50 of 2.5 nM.
In UM-UC-9 xenograft-bearing mice, BAY-0069 demonstrated a modest downregulation of FABP4 expression, comparable with that of SR10221, despite more robust in vitro inverse agonism in NCOR2 recruitment, RT112-FABP4-NLucP luciferase repression, and UM-UC-9 proliferation.
| M.Wt | 466.291 | |
| Formula | C22H16BrN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-bromo-N-(2-(4-ethylphenyl)benzo[d]oxazol-5-yl)-5-nitrobenzamide |
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1. Douglas L Orsi, et al. J Med Chem. 2022 Oct 21. doi: 10.1021/acs.jmedchem.2c01379.
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