BAY-293 racemate |CAS:2244904-14-9 Probechem Biochemicals

Chemical Structure : BAY-293 racemate

BAY-293 racemate (BAY293 racemate)

Catalog No.: PC-36031Not For Human Use, Lab Use Only.

BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM).

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Biological Activity

BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM).

Physicochemical Properties

M.Wt	448.585
Formula	C25H28N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine

References

1. Hillig RC, et al. Proc Natl Acad Sci U S A. 2019 Jan 25. pii: 201812963. doi: 10.1073/pnas.1812963116.

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BAY-293 racemate (BAY293 racemate)

Biological Activity

Physicochemical Properties

References

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