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Chemical Structure : BAY-4931
Catalog No.: PC-49399Not For Human Use, Lab Use Only.
BAY-4931 (BAY4931) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.17 nM in cellular reporter assays.
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BAY-4931 (BAY4931) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.17 nM in cellular reporter assays.
BAY-4931 displays no signigicant acitivity against PPARA, PPARD and additional high homology PXR (IC50 values >50 uM).
BAY-4931 inhibits proliferation of PPARG-amplified cell line UM-UC-9 with IC50 of 3.4 nM.
BAY-4931 showed antiproliferative effects across UM-UC-9, HuP-T4, and PaCaDD-188 sensitive cell lines in the colony formation assays.
| M.Wt | 421.837 | |
| Formula | C22H16ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Douglas L Orsi, et al. J Med Chem. 2022 Oct 21. doi: 10.1021/acs.jmedchem.2c01379.
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