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BAY-6035

Chemical Structure : BAY-6035

CAS No.: 2247890-13-5

BAY-6035 (BAY6035)

Catalog No.: PC-63250Not For Human Use, Lab Use Only.

BAY-6035 is a potent, peptide-competitive inhibitor of histone methyltransferase SMYD3, inhibits in vitro methylation of MEKK2 peptide with IC50 of 88 nM, >100-fold selectivity over other HMTases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BAY-6035 is a potent, peptide-competitive inhibitor of histone methyltransferase SMYD3, inhibits in vitro methylation of MEKK2 peptide with IC50 of 88 nM, >100-fold selectivity over other HMTases; inhibits the methylation of MEKK2 in cells with IC50 of 70 nM.

    Physicochemical Properties

    M.Wt 396.491
    Formula C22H28N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2S)-1-(3-azabicyclo[3.1.0]hexane-3-carbonyl)-N-(2-cyclopropylethyl)-2-methyl-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carboxamide

    References

    1, Stefan Gradl, et al. SLAS Discov. 2021 Sep;26(8):947-960.

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