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BAY1128688

Chemical Structure : BAY1128688

CAS No.: 1428988-21-9

BAY1128688 (BAY-1128688)

Catalog No.: PC-20086Not For Human Use, Lab Use Only.

BAY1128688 is a potent, selective steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 1.4 nM (human AKR1C3).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY1128688 is a potent, selective steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 1.4 nM (human AKR1C3).
BAY1128688 shows no inhibition of AKR1C1, AKR1C2, and AKR1C4 at concentrations up to 10 uM.

Physicochemical Properties

M.Wt 462.57
Formula C28H31FN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((8S,9S,13S,14S)-17-(5-fluoropyridin-3-yl)-N,13-dimethyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamido)propanoic acid

References

1. Rižner TL, et al. Pharmacol Res. 2020 Feb;152:104446.

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