Catalog No.: PC-38730Not For Human Use, Lab Use Only.
BAY 1214784 (BAY-784) is an orally available, potent, and selective antagonist of gonadotropin-releasing hormone receptor (GnRH-R) with IC50 of 21/ 24/ 35 nM for human/rat/cynomolgus GnRH-R, respectively.
BAY 1214784 (BAY-784) is an orally available, potent, and selective antagonist of gonadotropin-releasing hormone receptor (GnRH-R) with IC50 of 21/ 24/ 35 nM for human/rat/cynomolgus GnRH-R, respectively.
BAY 1214784 showed no agonistic activity in the human GnRH-R up to 20 uM, and was inactive in a cell-based panel of 25 GPCRs.
BAY 1214784 (10 and 30 mg/kg, p.o.) demonstrated suppression of plasma luteinizing hormone levels in OVX rats and ORX cynomolgus monkeys.
