BAY 60-6583 (BAY606583) is a potent, selective adenosine A2B receptor agonist with EC50 of 2.83 nM (murine A2BR).
BAY 60-6583 inhibits fMLP-stimulated superoxide production by either naive neutrophils,TNF-α-primed neutrophils, or neutrophils isolated from mice at 1-10 nM.
BAY 60-6583 increases fMLP-stimulated superoxide production at higher concentrations (>1 uM)。
BAY 60-6583 exhibits cardioprotective activity, attenuates infarct size in mouse model of myocardial ischemia.
