Catalog No.: PC-61626Not For Human Use, Lab Use Only.
BC-1471 is a selective, small-molecule deubiquitinase STAM-binding protein (STAMBP) inhibitor (IC50=0.33 uM) that interrupts STAMBP-Ub-NALP7 interaction.
BC-1471 is a selective, small-molecule deubiquitinase STAM-binding protein (STAMBP) inhibitor (IC50=0.33 uM) that interrupts STAMBP-Ub-NALP7 interaction.
BC-1471 blocks STAMBP mediated deubiquitination of Ub-NALP7 in vitro, decreases endogenous NALP7 abundance in THP-1 cells, but not NALP6, NALP3, ASC or pro-caspase-1.
BC-1471 suppresses IL-1β release in several complementary human inflammatory systems, including THP-1 monocyte/macrophages, PBMCs and lung organ culture.
