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Chemical Structure : BC-1471
CAS No.: 896683-84-4
Catalog No.: PC-61626Not For Human Use, Lab Use Only.
BC-1471 is a selective, small-molecule deubiquitinase STAM-binding protein (STAMBP) inhibitor (IC50=0.33 uM) that interrupts STAMBP-Ub-NALP7 interaction.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $578 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BC-1471 is a selective, small-molecule deubiquitinase STAM-binding protein (STAMBP) inhibitor (IC50=0.33 uM) that interrupts STAMBP-Ub-NALP7 interaction.
BC-1471 blocks STAMBP mediated deubiquitination of Ub-NALP7 in vitro, decreases endogenous NALP7 abundance in THP-1 cells, but not NALP6, NALP3, ASC or pro-caspase-1.
BC-1471 suppresses IL-1β release in several complementary human inflammatory systems, including THP-1 monocyte/macrophages, PBMCs and lung organ culture.
| M.Wt | 508.637 | |
| Formula | C27H32N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-2-((6-Morpholino-4-oxo-3-phenethyl-3,4-dihydroquinazolin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide |
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1. Bednash JS, et al. Nat Commun. 2017 May 11;8:15203.
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