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Chemical Structure : BC-21
Catalog No.: PC-61811Not For Human Use, Lab Use Only.
BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM.
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BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM.
BC-21 (NSC 109268) decreases the viability of β-catenin overexpressing HCT116 colon cancer cells that harbor the β-catenin mutation, and inhibits the clonogenic activity of these cells.
BC-21 (NSC 109268) inhibits Wnt/β-catenin signaling and down-regulates c-Myc and cyclin D1 expression in HCT116 cells.
| M.Wt | 680.659 | |
| Formula | C32H36Cl2Cu2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tian W, et al. Biochemistry. 2012 Jan 17;51(2):724-31.
2. Tian W, et al. J Biomol Screen. 2012 Apr;17(4):530-4.
3. Jain D, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):945-52.
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