BC-21 |CAS:691005-38-6 Probechem Biochemicals

Chemical Structure : BC-21

BC-21 (NSC 109268;BC21)

Catalog No.: PC-61811Not For Human Use, Lab Use Only.

BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM.

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Biological Activity

BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM.
BC-21 (NSC 109268) decreases the viability of β-catenin overexpressing HCT116 colon cancer cells that harbor the β-catenin mutation, and inhibits the clonogenic activity of these cells.
BC-21 (NSC 109268) inhibits Wnt/β-catenin signaling and down-regulates c-Myc and cyclin D1 expression in HCT116 cells.

Physicochemical Properties

M.Wt	680.659
Formula	C32H36Cl2Cu2N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Di-μ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]dicopper

References

1. Tian W, et al. Biochemistry. 2012 Jan 17;51(2):724-31.

2. Tian W, et al. J Biomol Screen. 2012 Apr;17(4):530-4.

3. Jain D, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):945-52.

BC-21 (NSC 109268;BC21)

Biological Activity

Physicochemical Properties

References

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