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Chemical Structure : BC-23
CAS No.: 6298-15-3
Catalog No.: PC-61804Not For Human Use, Lab Use Only.
BC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $528 | In stock | |
| 100 mg | Get quote |
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BC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM.
BC-23 dose-dependently inhibits TOP-luciferase activity in H1299 cells with IC50 of 2.3 uM.
BC-23 causes strong synergistic enhancement of the cancer cell death induced by low doses of radiation.
BC-23 effectively inhibits Wnt/β-catenin signaling and down-regulates c-Myc and cyclin D1 expression, induces S phase and ROS generation, and overcomes radioresistance in human NSCLC cells.
| M.Wt | 439.87 | |
| Formula | C21H14ClN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]-N-pyridin-2-ylbenzenesulfonamide |
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1. Zhang Q, et al. PLoS One. 2016 Mar 25;11(3):e0152407.
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