BCI-137 | AGO2 inhibitor | Probechem Biochemicals

Chemical Structure : BCI-137

CAS No.: 112170-24-8

BCI-137 (BCI137)

Catalog No.: PC-62379Not For Human Use, Lab Use Only.

BCI-137 is a chemical compound able to compete with Argonaute 2 (Ago2) miRNAs binding, binds to Ago2 with Kd of 126 uM.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
50 mg	$298	In stock
100 mg		Get quote

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Biological Activity

BCI-137 is a chemical compound able to compete with Argonaute 2 (Ago2) miRNAs binding, binds to Ago2 with Kd of 126 uM.
BCI-137 displaces Ago2 from the miR-155 host gene promoter paralleling an increase in histone H4 acetylation, favors RA-induced differentiation of the APL cell line NB4.

Physicochemical Properties

M.Wt	313.284
Formula	C11H11N3O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamido)propanoic acid

References

1. Masciarelli S, et al. ACS Chem Biol. 2014 Aug 15;9(8):1674-9.

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BCI-137 (BCI137)

Biological Activity

Physicochemical Properties

References

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