BCX1470 methanesulfonate is a potent serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).
BCX1470 methanesulfonate displays 3.4-fold and 200-fold bette than that of trypsin, respectively.
BCX1470 methanesulfonate inhibits esterolytic activity translates into potent inhibition of the proteolytic activity of C1s, factor D, and consequently of the classical and alternative pathway-mediated hemolysis of target RBC (IC50=46 nM and 330 nM, respectively).
BCX1470 methanesulfonate blocks the reverse passive Arthus (RPA) reaction in rats.
