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BF844

Chemical Structure : BF844

CAS No.: 1404506-35-9

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BF844 (BioFocus 844)

Catalog No.: PC-62222Not For Human Use, Lab Use Only.

BF844 (BioFocus 844) is a small molecules capable of stabilizing mutant USH3 mutation CLRN1(N48K).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BF844 (BioFocus 844) is a small molecules capable of stabilizing mutant USH3 mutation CLRN1(N48K).
    BF844 effectively attenuated progressive hearing loss and prevented deafness in mouse model potentially prevents both sensory deficiencies in patients with USH3.

    Physicochemical Properties

    M.Wt 378.85
    Formula C21H19ClN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl)-2-methylpropan-2-ol

    References

    1. Alagramam KN, et al. Nat Chem Biol. 2016 Jun;12(6):444-51.

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