Catalog No.: PC-43234Not For Human Use, Lab Use Only.
BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells.
BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells.
BHPI distorts this normal action of E2–ERα and induces a massive and sustained ERα-dependent activation of the unfolded protein response (UPR), persistent inhibition of protein synthesis, converting UPR activation from cytoprotective to cytotoxic.
BHPI completely blocked proliferation of ERα+ cancer cells at 100-1000 nM, induces tumor regression in mouse xenograft of MCF-7 cells.
