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Chemical Structure : BHPI
CAS No.: 56632-39-4
Catalog No.: PC-43234Not For Human Use, Lab Use Only.
BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $125 | In stock | |
| 25 mg | $325 | In stock | |
| 100 mg | $895 | In stock | |
| 500 mg | Get quote |
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BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells; distorts this normal action of E2–ERα and induces a massive and sustained ERα-dependent activation of the unfolded protein response (UPR), persistent inhibition of protein synthesis, converting UPR activation from cytoprotective to cytotoxic; completely blocked proliferation of ERα+ cancer cells at 100-1000 nM, induces tumor regression in mouse xenograft of MCF-7 cells.
| M.Wt | 331.3646 | |
| Formula | C21H17NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥150 mg/mL |
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| Chemical Name/SMILES |
2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl- |
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1. Andruska ND, et al. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42.
2. Zheng X, et al. Oncotarget. 2016 Jul 24;9(19):14741-14753.
3. Mao C, et al. Sci Rep. 2016 Oct 7;6:34753.
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