BI-1830

Chemical Structure : BI-1830

Catalog No.: PC-26309Not For Human Use, Lab Use Only.

BI-1830 is a specific small molecule KRAS(G12D)-D92C binder, binds to D92-adjacent pocket stabilizes KRAS and inhibits signaling, inhibits phospho-ERK levels in KRAS(G12D)-D92C cells.

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Biological Activity

BI-1830 is a specific small molecule KRAS(G12D)-D92C binder, binds to D92-adjacent pocket stabilizes KRAS and inhibits signaling, inhibits phospho-ERK levels in KRAS(G12D)-D92C cells.

Physicochemical Properties

M.Wt	366.26
Formula	C16H20BrN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((4-bromo-2-methylphenyl)glycyl)piperazin-1-yl)prop-2-en-1-one

References

1. van Tienen LM, et al. Cell Chem Biol. 2026 Feb 19;33(2):241-255.e8.

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BI-1830

Biological Activity

Physicochemical Properties

References

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