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BI-1935

Chemical Structure : BI-1935

CAS No.: 940954-41-6

BI-1935 (BI1935)

Catalog No.: PC-63248Not For Human Use, Lab Use Only.

BI-1935 is a potent, selective small molecule inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BI-1935 is a potent, selective small molecule inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 7 nM.
BI-1935 is also highly active in a cellular Hep G2-DHET assay format with IC50 of <1 nM.
BI-1935 can also be used in vivo and showed a dose dependent effect on mean arterial pressure blood pressure in Dahl salt sensitive rats.
BI-1935 also shows good selectivity against hCYP epoxygenases 2J2/2C9/2C19 and IL-2.

Physicochemical Properties

M.Wt 498.466
Formula C24H21F3N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(2-ethoxyethyl)-6-oxo-N-(5-(3-(pyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-2-yl)-1,6-dihydropyridine-3-carboxamide

References

1. Patent WO2007067836A2.

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