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Chemical Structure : BI-2545
CAS No.: 2162961-71-7
Catalog No.: PC-60142Not For Human Use, Lab Use Only.
BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively.
BI-2545 displays good potency in the LPA and rat whole blood assay (IC50=29 nM).
BI-2545 shows substantial lowering of LPA in vivo, and excellent PK/Target Engagement relationship.
| M.Wt | 527.427 | |
| Formula | C23H19F6N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3,5-bis(trifluoromethyl)benzyl (1R,5S,6r)-6-((1H-benzo[d][1,2,3]triazole-5-carboxamido)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate |
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1. Christian A. Kuttruff, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1252-1257. DOI: 10.1021/acsmedchemlett.7b00312
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