BI-69A11 is a potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1.
BI-69A11 displays no activity for other protein kinases including Abl1, p38α, JNK, and PI3K (IC50>100 uM).
BI-69A11 causes partial inhibition of AKT phosphorylation on S473 on melanoma cells at 3 uM.
BI-69A11 reduces AKT protein expression and AKT association with HSP-90.|
BI-69A11 caused effective regression of melanoma tumor xenografts.
