Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BI-69A11
Catalog No.: PC-70086Not For Human Use, Lab Use Only.
BI-69A11 is a potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BI-69A11 is a potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1.
BI-69A11 displays no activity for other protein kinases including Abl1, p38α, JNK, and PI3K (IC50>100 uM).
BI-69A11 causes partial inhibition of AKT phosphorylation on S473 on melanoma cells at 3 uM.
BI-69A11 reduces AKT protein expression and AKT association with HSP-90.|
BI-69A11 caused effective regression of melanoma tumor xenografts.
| M.Wt | 425.872 | |
| Formula | C25H16ClN3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Gaitonde S, et al. Pigment Cell Melanoma Res. 2009 Apr;22(2):187-95.
2. Feng Y, et al. Pigment Cell Melanoma Res. 2013 Jan;26(1):136-42.
3. Pal I, et al. Br J Cancer. 2014 Jul 8;111(1):101-11.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
