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Chemical Structure : BI 689648
CAS No.: 1633009-87-6
Catalog No.: PC-60700Not For Human Use, Lab Use Only.
BI 689648 is a potent, selective, orally active aldosterone synthase (CYP11B2) inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase ((CYP11B1).
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| 10 mg | $378 | In stock | |
| 25 mg | $598 | In stock | |
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BI 689648 is a potent, selective, orally active aldosterone synthase (CYP11B2) inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase ((CYP11B1).
BI 689648 demonstrates good in vivo profiling used an adrenocorticotropin-challenge model in which BI 689648 is >20-fold more selective compared with FAD286 and LCI699.
| M.Wt | 298.346 | |
| Formula | C16H18N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(5-methoxymethyl-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide |
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1. Weldon SM, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):142-50.
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