Catalog No.: PC-60700Not For Human Use, Lab Use Only.
BI 689648 is a potent, selective, orally active aldosterone synthase (CYP11B2) inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase ((CYP11B1).
BI 689648 is a potent, selective, orally active aldosterone synthase (CYP11B2) inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase ((CYP11B1).
BI 689648 demonstrates good in vivo profiling used an adrenocorticotropin-challenge model in which BI 689648 is >20-fold more selective compared with FAD286 and LCI699.
