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BI 831266

Chemical Structure : BI 831266

CAS No.: 958227-46-8

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BI 831266 (BI831266)

Catalog No.: PC-63253Not For Human Use, Lab Use Only.

BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.
BI 831266 inhibits the proliferation of human non-small cell lung cancer (NSCLC), pancreatic cancer, and prostate cancer cell lines (H460 tumor cell proliferation inhibition IC50=11 nM).
BI 831266 causes tumor regression and growth inhibition in in murine xenograft tumor models (HCT 116 colon carcinoma, BxPC3 pancreatic adenocarcinoma, and NCI-H460 NSCLC).

Physicochemical Properties

M.Wt 528.098
Formula C27H38ClN7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((5-chloro-4-(((1R,2S)-2-(isopropylcarbamoyl)cyclopentyl)amino)pyrimidin-2-yl)amino)-N-methyl-N-(1-methylpiperidin-4-yl)benzamide

References

1. Dittrich C, et al. Invest New Drugs. 2015 Apr;33(2):409-22.

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