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Chemical Structure : BI 831266
Catalog No.: PC-63253Not For Human Use, Lab Use Only.
BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.
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BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.
BI 831266 inhibits the proliferation of human non-small cell lung cancer (NSCLC), pancreatic cancer, and prostate cancer cell lines (H460 tumor cell proliferation inhibition IC50=11 nM).
BI 831266 causes tumor regression and growth inhibition in in murine xenograft tumor models (HCT 116 colon carcinoma, BxPC3 pancreatic adenocarcinoma, and NCI-H460 NSCLC).
| M.Wt | 528.098 | |
| Formula | C27H38ClN7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dittrich C, et al. Invest New Drugs. 2015 Apr;33(2):409-22.
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