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BIBR1523

Chemical Structure : BIBR1523

CAS No.: 321674-73-1

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BIBR1523 (BIBR-1532, BIBR 1532)

Catalog No.: PC-45170Not For Human Use, Lab Use Only.

BIBR1532 is a potent and selective telomerase inhibitor with IC50 of 100 nM in cell-free assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BIBR1532 is a potent and selective telomerase inhibitor with IC50 of 100 nM in cell-free assays.
BIBR1532 shows selective cytotoxicity and telomere damage in leukemia cells with IC50 of 30-80 uM.
BIBR1532 also sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment.

Physicochemical Properties

M.Wt 331.3646
Formula C21H17NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzoic acid, 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-buten-1-yl]amino]-

References

1. Barma DK, et al. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1333-6.

2. Pascolo E, et al. J Biol Chem. 2002 May 3;277(18):15566-72.

3. Ward RJ, et al. Mol Pharmacol. 2005 Sep;68(3):779-86.

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