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Chemical Structure : BIIB-TTBKi
Catalog No.: PC-22793Not For Human Use, Lab Use Only.
BIIB-TTBK1i is a potent selective inhibitor of CNS-specific tau kinase Tau Tubulin Kinase 1 (TTBK1) with IC50 of 9.5 nM in recombinant kinase assay, inhibits tau phosphorylation at S422 (pS422) with IC50 of 9.75 nM in cell-based assays.
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BIIB-TTBK1i is a potent selective inhibitor of CNS-specific tau kinase Tau Tubulin Kinase 1 (TTBK1) with IC50 of 9.5 nM in recombinant kinase assay, inhibits tau phosphorylation at S422 (pS422) with IC50 of 9.75 nM in cell-based assays.
BIIB-TTBK1i demonstrates in vivo target engagement and kinome selectivity.
BIIB-TTBK1i (50 or 75mg/kg) reduces tau phosphorylation at disease relevant sites in vivo.
| M.Wt | 307.36 | |
| Formula | C17H17N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dillon GM, et al. PLoS One. 2020 Apr 7;15(4):e0228771.
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