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BIIB-TTBKi

Chemical Structure : BIIB-TTBKi

CAS No.: 2735014-96-5

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BIIB-TTBKi

Catalog No.: PC-22793Not For Human Use, Lab Use Only.

BIIB-TTBK1i is a potent selective inhibitor of CNS-specific tau kinase Tau Tubulin Kinase 1 (TTBK1) with IC50 of 9.5 nM in recombinant kinase assay, inhibits tau phosphorylation at S422 (pS422) with IC50 of 9.75 nM in cell-based assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BIIB-TTBK1i is a potent selective inhibitor of CNS-specific tau kinase Tau Tubulin Kinase 1 (TTBK1) with IC50 of 9.5 nM in recombinant kinase assay, inhibits tau phosphorylation at S422 (pS422) with IC50 of 9.75 nM in cell-based assays.
    BIIB-TTBK1i demonstrates in vivo target engagement and kinome selectivity.
    BIIB-TTBK1i (50 or 75mg/kg) reduces tau phosphorylation at disease relevant sites in vivo.

    Physicochemical Properties

    M.Wt 307.36
    Formula C17H17N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(1-(2-aminopyrimidin-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)-3-methylpent-1-yn-3-ol

    References

    1. Dillon GM, et al. PLoS One. 2020 Apr 7;15(4):e0228771.

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