Catalog No.: PC-38252Not For Human Use, Lab Use Only.
BIIE0246 (BIIE 0246) is a potent, highly selective non-peptide neuropeptide Y Y2 receptor antagonist with IC50 of 15 nM, >650-fold selectivity over Y1, Y4 and Y5 receptors.
BIIE0246 (BIIE 0246) is a potent, highly selective non-peptide neuropeptide Y Y2 receptor (NPY2R)antagonist with IC50 of 15 nM, >650-fold selectivity over Y1, Y4 and Y5 receptors.
BIIE0246 (1 uM) completely blocked the contraction induced by PYY(3-36), but not that of [Leu(31), Pro(34)]NPY (a Y(1), Y(4) and Y(5) agonist) and hPP (a Y(4) and Y(5) agonist).
BIIE0246 displaced [125I]neuropeptide Y with high affinity (IC(50)=3.3 nM) from the human neuropeptide Y Y(2) receptor and proved to be highly selective.
