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Chemical Structure : BIIE0246
CAS No.: 246146-55-4
Catalog No.: PC-38252Not For Human Use, Lab Use Only.
BIIE0246 (BIIE 0246) is a potent, highly selective non-peptide neuropeptide Y Y2 receptor antagonist with IC50 of 15 nM, >650-fold selectivity over Y1, Y4 and Y5 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BIIE0246 (BIIE 0246) is a potent, highly selective non-peptide neuropeptide Y Y2 receptor (NPY2R) antagonist with IC50 of 15 nM, >650-fold selectivity over Y1, Y4 and Y5 receptors.
BIIE0246 (1 uM) completely blocked the contraction induced by PYY(3-36), but not that of [Leu(31), Pro(34)]NPY (a Y(1), Y(4) and Y(5) agonist) and hPP (a Y(4) and Y(5) agonist).
BIIE0246 displaced [125I]neuropeptide Y with high affinity (IC(50)=3.3 nM) from the human neuropeptide Y Y(2) receptor and proved to be highly selective.
| M.Wt | 896.066 | |
| Formula | C49H57N11O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide |
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1. Doods H,et al. Eur J Pharmacol. 1999 Nov 19;384(2-3):R3-5.
2. Malmström RE. Br J Pharmacol. 2001 Aug;133(7):1073-80.
3. Goumain M, et al. Mol Pharmacol. 2001 Jul;60(1):124-34.
4. Smith-White MA, et al. Br J Pharmacol. 2001 Feb;132(4):861-8.
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