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BIO 8898

Chemical Structure : BIO 8898

CAS No.: 402564-79-8

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BIO 8898 (BIO8898)

Catalog No.: PC-62356Not For Human Use, Lab Use Only.

BIO 8898 is a synthetic, CD40-CD154 co-stimulatory interaction inhibitor that inhibits the TNF family cytokine CD40L binding to CD40-Ig with a potency of IC50=25 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BIO 8898 is a synthetic, CD40-CD154 co-stimulatory interaction inhibitor that inhibits the TNF family cytokine CD40L binding to CD40-Ig with a potency of IC50=25 uM.
    BIO 8898 inhibits CD40L-dependent apoptosis in a cellular assay.

    Physicochemical Properties

    M.Wt 909.145
    Formula C53H64N8O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(2'-(([1,1'-biphenyl]-3-ylmethyl)carbamoyl)-6,6'-bis((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-[4,4'-bipyridine]-2-carboxamido)-2-cyclohexylacetic acid

    References

    1. Silvian LF, et al. ACS Chem Biol. 2011 Jun 17;6(6):636-47.

    2. Ganesan L, et al. Pharmazie. 2012 May;67(5):374-9.

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