BK50118-C is a potent small molecule inhibitor of ubiquitin-specific protease-13 (USP13) with IC50 of 0.42 nM.
BK50118-C potently decreased alpha-synuclein levels, reaching almost complete alpha-synuclein clearance at 1 mM and 100 µM via measurement of human alpha-synuclein via ELISA.
BK50118-C (daily dosage of 10 mg/Kg or 40 mg/Kg for 7 days) significantly reduced alpha-synuclein but not p-tau levels in TgA53T mice, reduced the number of human alpha-synuclein positive neurons by 42% in cortex and 40% in striatum.
BK50118-C significantly increased alpha-synuclein ubiquitination but had minimal effects on tyrosine hydroxylase (TH) levels in striatum of TgA53T mice.
BK50118-C (100 mg/kg) significantly reduced ubiquitinated alpha-synuclein, increased dopamine levels, and improved motor and behavioral symptoms in wild-type (USP13+/+), but not USP13 deficient, mice.
Physicochemical Properties
M.Wt
253.28
Formula
C16H12FNO
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-(benzyloxy)-6-fluoroquinoline
References
1. Xiaoguang Liu, et al. Metabolites. 2021 Sep 15;11(9):622.
