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BKI-1369

Chemical Structure : BKI-1369

CAS No.: 1951431-22-3

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BKI-1369 (BKI1369)

Catalog No.: PC-63462Not For Human Use, Lab Use Only.

BKI-1369 is an effective bumped kinase inhibitor (BKI), inhibits Theileria equi in vitro and reduces parasite burden and disease severity in the gnotobiotic pig model.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BKI-1369 is an effective bumped kinase inhibitor (BKI), inhibits Theileria equi in vitro and reduces parasite burden and disease severity in the gnotobiotic pig model.
    BKI-1369 exhibits a significant reduction of oocyst excretion, mucosal colonization by C. hominis, and mucosal lesions, which resulted in considerable symptomatic improvement.

    Physicochemical Properties

    M.Wt 417.517
    Formula C23H27N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(2-ethoxyquinolin-6-yl)-1-((1-methylpiperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

    References

    1. Lee S, et al. Antimicrob Agents Chemother. 2018 Apr 16. pii: AAC.00147-18.

    2. Hulverson MA, et al. Int J Parasitol. 2017 Oct;47(12):753-763.

    3. Gimenez F, et al. Vet Parasitol. 2018 Feb 15;251:90-94.

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