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BKI-1369

Chemical Structure : BKI-1369

CAS No.: 1951431-22-3

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BKI-1369 (BKI1369)

Catalog No.: PC-63462Not For Human Use, Lab Use Only.

BKI-1369 is an effective bumped kinase inhibitor (BKI), inhibits Theileria equi in vitro and reduces parasite burden and disease severity in the gnotobiotic pig model.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BKI-1369 is an effective bumped kinase inhibitor (BKI), inhibits Theileria equi in vitro and reduces parasite burden and disease severity in the gnotobiotic pig model; exhibits a significant reduction of oocyst excretion, mucosal colonization by C. hominis, and mucosal lesions, which resulted in considerable symptomatic improvement.

Physicochemical Properties

M.Wt 417.517
Formula C23H27N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(2-ethoxyquinolin-6-yl)-1-((1-methylpiperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

References

1. Lee S, et al. Antimicrob Agents Chemother. 2018 Apr 16. pii: AAC.00147-18.

2. Hulverson MA, et al. Int J Parasitol. 2017 Oct;47(12):753-763.

3. Gimenez F, et al. Vet Parasitol. 2018 Feb 15;251:90-94.

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