Chemical Structure : BKT300
CAS No.:
2551033-16-8
BKT300
(BKT-300)
Catalog No.: PC-24282Not For Human Use, Lab Use Only.
BKT300 is a small molecule inhibitor of leukemic cell migration and survival by targeting the PRC1 pathways, efficiently and specifically binds protein regulator of cytokinesis 1 (PRC1) with SPR Kd of 28.3 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BKT300 is a small molecule inhibitor of leukemic cell migration and survival by targeting the PRC1 pathways, efficiently and specifically binds protein regulator of cytokinesis 1 (PRC1) with SPR Kd of 28.3 nM.
BKT300 does not bind to CDC25C or DCAF11.
BKT300 inhibits the migration of AML THP-1 cells toward monocyte chemotactic protein-1 (MCP-1).
BKT300 inhibits the formation and organization of actin filaments and microtubules.
BKT300 arrests cancer cells at G2/M and induces apoptotic cell death through the caspase 3 pathway, downregulates the expression of CDC25C but not CDC2 and upregulates p21.
BKT300 arrests PRC1 in a phosphorylated state at position T481.
BKT300 inhibits tumor growth and induces tumor regression in xenograft mouse models of AML.
Physicochemical Properties
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M.Wt
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399.44
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Formula
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C22H25NO6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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8-(4-hydroxy-2-methoxyphenoxy)-6-methoxy-3-pentylquinoline-2,4-diol
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References
1. Amnon Peled, et al. Res Sq [Preprint]. 2025 Feb 19:rs.3.rs-6017610.
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