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Chemical Structure : BL-1020
Catalog No.: PC-63550Not For Human Use, Lab Use Only.
BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist.
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BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist; reduces dopamine activity and enhances GABAA activity, shows pro-cognitive effects and potential for the treatment of schizophrenia; displays strong dopamine and serotonin (5HT) receptor inhibition ((D2LK(iz)=0.066 nM, D(2S)Ki=0.062 nM, 5-HT2A Ki=0.21 nM).
Schizophrenia
Phase 2 Discontinued
| M.Wt | 525.533 | |
| Formula | C25H34Cl2N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Geffen Y, et al. Eur Neuropsychopharmacol. 2009 Jan;19(1):1-13.
2. Nudelman A, et al. J Med Chem. 2008 May 8;51(9):2858-62.
3. Appel L, et al. Eur Neuropsychopharmacol. 2009 Dec;19(12):841-50.
4. Geffen Y, et al. J Clin Psychiatry. 2012 Sep;73(9):e1168-74.
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