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Chemical Structure : BMK-C205
Catalog No.: PC-21195Not For Human Use, Lab Use Only.
BMK-C205 (BMK-C 205) is a potent, selective corticotropin-releasing hormone receptor 1 (CRF1R) antagonist with IC50 of 74 nM in calcium mobilization assays, blocks hypothalamus-pituitary-adrenal (HPA) axis activation.
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BMK-C205 (BMK-C 205) is a potent, selective corticotropin-releasing hormone receptor 1 (CRF1R) antagonist with IC50 of 74 nM in calcium mobilization assays, blocks hypothalamus-pituitary-adrenal (HPA) axis activation.
BMK-C205 displays >100-fold selectivity over CRF2R.
BMK-C205 exhibits minimal inhibition against five major CYP450 isoforms at a concentration of 10 μM.
BMK-C205 (30 mg/kg, orally administered for 3 days) shows in vivo antidepressant response in mice, without causing hyperactivity, significantly decreases adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels in treated mice.
| M.Wt | 488.43 | |
| Formula | C23H30BrN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hoyoung Kim, et al. Exp Mol Med. 2023 Sep 1. doi: 10.1038/s12276-023-01082-1.
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