Chemical Structure : BMK-C205
CAS No.:
2950971-22-7
BMK-C205
(BMK-C 205)
Catalog No.: PC-21195Not For Human Use, Lab Use Only.
BMK-C205 (BMK-C 205) is a potent, selective corticotropin-releasing hormone receptor 1 (CRF1R) antagonist with IC50 of 74 nM in calcium mobilization assays, blocks hypothalamus-pituitary-adrenal (HPA) axis activation.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BMK-C205 (BMK-C 205) is a potent, selective corticotropin-releasing hormone receptor 1 (CRF1R) antagonist with IC50 of 74 nM in calcium mobilization assays, blocks hypothalamus-pituitary-adrenal (HPA) axis activation.
BMK-C205 displays >100-fold selectivity over CRF2R.
BMK-C205 exhibits minimal inhibition against five major CYP450 isoforms at a concentration of 10 μM.
BMK-C205 (30 mg/kg, orally administered for 3 days) shows in vivo antidepressant response in mice, without causing hyperactivity, significantly decreases adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels in treated mice.
Physicochemical Properties
|
M.Wt
|
488.43
|
|
Formula
|
C23H30BrN5O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
8-(4-bromo-2,6-dimethoxyphenyl)-N-butyl-N-(cyclopropylmethyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
|
References
1. Hoyoung Kim, et al. Exp Mol Med. 2023 Sep 1. doi: 10.1038/s12276-023-01082-1.
Contact Us
sales@probechem.com
