BMP22

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Chemical Structure : BMP22

Catalog No.: PC-23708Not For Human Use, Lab Use Only.

BMP22 is a potent inhibitor of autotaxin (ATX, NPP2) with Ki/IC50 of 0.17/0.27 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMP22 is a potent inhibitor of autotaxin (ATX, NPP2) with Ki/IC50 of 0.17/0.27 uM.
BMP22 inhibited ATX-dependent invasion of rat MM1 hepatoma cells of mesothelial cell and human umbilical cord vascular endothelial cell (HUVEC) monolayers in vitro.
BMP22 showed a profound reduction in lung foci in vivo using the B16-F10 syngeneic melanoma metastasis model in C57BL/6 mice.

Physicochemical Properties

M.Wt	426.49
Formula	C22H37Na2O3P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (4-pentadecylbenzyl)phosphonate

References

1. Sue-Chin Lee, et al. Mol Cancer Res. 2015 Jan;13(1):174-85.

2. Renuka Gupte, et al. ChemMedChem. 2011 May 2;6(5):922-35.

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BMP22

Biological Activity

Physicochemical Properties

References

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