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Chemical Structure : BMS-189453
CAS No.: 166977-43-1
Catalog No.: PC-70294Not For Human Use, Lab Use Only.
BMS-189453 (BMS189453, BMS453) is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BMS-189453 (BMS189453, BMS453) is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.
BMS-189453 binds to RAR receptors and transrepresses AP-1, inhibits the growth of normal breast cells (HMEC and 184) and T47D breast cancer cells.
BMS-189453 increases p21, decrease CDK2 kinase activity, which in turn leads to hypophosphorylation of Rb and G1 arrest.
| M.Wt | 380.5 | |
| Formula | C27H24O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]- (9CI) |
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1. Chen JY, et al. EMBO J. 1995 Mar 15;14(6):1187-97.
2. Yang L, et al. Oncogene. 2001 Nov 29;20(55):8025-35.
3. Yang L, et al. Breast Cancer Res Treat. 1999 Aug;56(3):277-91.
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