Catalog No.: PC-26144Not For Human Use, Lab Use Only.
BMS-193885 is a potent, selective neuropeptide Y(1) receptor (Y1R) antagonist with binding Ki of 3.3 nM, demonstrates full functional antagonism with Kb of 4.54 nM in forskolin-stimulated c-AMP production assay using CHO cells expressing human Y(1) receptor.
BMS-193885 is a potent, selective neuropeptide Y(1) receptor (Y1R) antagonist with binding Ki of 3.3 nM, demonstrates full functional antagonism with Kb of 4.54 nM in forskolin-stimulated c-AMP production assay using CHO cells expressing human Y(1) receptor. BMS-193885 inhibited NPY-induced feeding in satiated rats when dosed at 3.0 and 10.0 mg/kg (ip), and also decreased spontaneous overnight food consumption in rats at doses of 10 and 20 mg/kg (ip). BMS-193885 (10 mg/kg) also reduced one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption.
