Catalog No.: PC-24422Not For Human Use, Lab Use Only.
BMS-214662 is a potent, selective farnesyltransferase (FTase) inhibitor with IC50 of 1.35 nM, inhibits anchorage-independent growth of H-ras transformed NIH3T3 cells in soft agar EC50 of 25 nM.
BMS-214662 is a potent, selective farnesyltransferase (FTase) inhibitor with IC50 of 1.35 nM, inhibits anchorage-independent growth of H-ras transformed NIH3T3 cells in soft agar EC50 of 25 nM.
BMS-214662 is over 1000-fold selective over the related enzyme GGT1.
BMS-214662 has IC50 values for inhibition of geranylgeranylation of Ras-CVLL and K-Ras of 1.3 and 2.3 μM, respectively.
BMS-214662 reversed the H-Ras-transformed phenotype but not that of K-Ras or other oncogenes.
BMS-214662 (300 mg/kg) achieved curative efficacy when given orally in the HCT-116 human colon tumor model.
BMS-214662 demonstrated broad spectrum activity against human tumors, but murine tumors were not as sensitive.
