BMS-22 |CAS: 445479-97-0 Probechem Biochemicals

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Chemical Structure : BMS-22

CAS No.: 445479-97-0

BMS-22 (BMS CCR2 22;CCR2 inhibitor BMS22)

Catalog No.: PC-60324Not For Human Use, Lab Use Only.

BMS-22 is a potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-22 is a potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM.
BMS-22 displays potent functional antagonism (calcium flux IC50=18 nM and chemotaxis IC 50=1 nM).

Physicochemical Properties

M.Wt	593.66
Formula	C28H34F3N5O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide

References

1. Zweemer AJ, et al. Mol Pharmacol. 2013 Oct;84(4):551-61.

2. Cherney RJ, et al. J Med Chem. 2008 Feb 28;51(4):721-4.

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BMS-22 (BMS CCR2 22;CCR2 inhibitor BMS22)

Biological Activity

Physicochemical Properties

References

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